US Patent Issued to ARVINAS OPERATIONS on Feb. 17 for "Modulators of proteolysis and associated methods of use" (Connecticut Inventors)

ALEXANDRIA, Va., Feb. 17 -- United States Patent no. 12,552,783, issued on Feb. 17, was assigned to ARVINAS OPERATIONS INC. (New Haven, Conn.).

"Modulators of proteolysis and associated methods of use" was invented by Andrew P. Crew (Chester, Conn.), Keith R. Hornberger (Southbury, Conn.), Jing Wang (Milford, Conn.) and Hanqing Dong (Madison, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to bifunctional compounds, which find utility as modulators of Kirsten rat sarcoma protein (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse doubl...