US Patent Issued to ARROWHEAD PHARMACEUTICALS on Oct. 14 for "5'-cyclo-phosphonate modified nucleotides" (Wisconsin Inventors)

ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,441,756, issued on Oct. 14, was assigned to ARROWHEAD PHARMACEUTICALS INC. (Pasadena, Calif.).

"5'-cyclo-phosphonate modified nucleotides" was invented by Zhen Li (San Diego, Wis.), Tao Pei (Middleton, Wis.) and Michael Lawler (Waunakee, Wis.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described are 5'-cyclo-phosphonate modified nucleotides, and oligonucleotides, such as interference (RNAi) agents, containing 5'-cyclo-phosphonate modified nucleotides. The RNAi agents having either double-stranded or single-stranded oligonucleotides described herein comprising 5'cyclo-phosphonate modified nucleotides are useful in modulating gene expression as well as...