ALEXANDRIA, Va., Jan. 20 -- United States Patent no. 12,527,881, issued on Jan. 20, was assigned to Arcturus Therapeutics Inc. (San Diego).
"Ionizable cationic lipid for RNA delivery" was invented by Joseph E. Payne (San Diego), Padmanabh Chivukula (San Diego), Priya Karmali (San Diego) and Steven P. Tanis (Carlsbad, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "What is described is a compound of formula Iconsisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons; R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L1 and L2 are the same or different, each a linear alkylene or alkenylene consisting of 2 to 20 carbons; X1 is S or O; R3 is a linea...