ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,485,143, issued on Dec. 2, was assigned to APPLIED STEMCELL INC. (Milpitas, Calif.).
"HLA-F-modified cells and methods" was invented by Ruby Yanru Tsai (San Jose, Calif.), Alfonso Farruggio (Stanford, Calif.), Xiuling Chi (San Jose, Calif.) and Kai Wang (Newark, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides compositions and methods for cell transplantation therapy based on forced expression of an exogenous HLA-F protein in donor cells to be transplanted into a subject. In some embodiments, the donor cells express an exogenous chimeric HLA-F protein comprising an extracellular region comprising an HLA-F alpha 1 doma...