US Patent Issued to Amgen on Sept. 30 for "Sequential digestion of polypeptides for mass spectrometric analysis" (California Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,429,405, issued on Sept. 30, was assigned to Amgen Inc. (Thousand Oaks, Calif.).

"Sequential digestion of polypeptides for mass spectrometric analysis" was invented by Da Ren (Thousand Oaks, Calif.) and Melissa Sato (Santa Monica, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosed methods are directed to preparing polypeptides for multi-attribute analysis. The polypeptides are optionally denatured, reduced, and/or alkylated before being subjected to a first digestion. Following the first digestion the large and small fragments resulting from the digestion are separated from each other. A second digestion is then performed on the larger...