ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,486, issued on March 18, was assigned to Amgen Inc. (Thousand Oaks, Calif.).
"Solid state forms" was invented by Mary Chaves (Arlington, Mass.), Ron C. Kelly (Westlake Village, Calif.), Prashant Agarwal (Chelsea, Mass.), Stephan D. Parent (West Lafayette, Ind.), Darren Leonard Reid (Belmont, Mass.) and Roman Shimanovich (Brighton, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a crystalline form and stable salts of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several hydrochloride salt form...