US Patent Issued to Altius Institute for Biomedical Sciences on Nov. 11 for "Compositions and methods for DNA modification detection" (Washington Inventors)

ALEXANDRIA, Va., Nov. 11 -- United States Patent no. 12,467,077, issued on Nov. 11, was assigned to Altius Institute for Biomedical Sciences (Seattle).

"Compositions and methods for DNA modification detection" was invented by John Stamatoyannopoulos (Seattle) and Pavel Zrazhevskiy (Seattle).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are methods and compositions for use in detecting on-target and/or off-target cleavage of genomic DNA in a cell by a nuclease. The on-target and off-target cleavage is detected by using oligonucleotides that bind to the single-stranded 3'-overhang created at the cleavage site. The nuclease may be an engineered nuclease comprising a nucleic acid binding domain t...