US Patent Issued to Allogene Therapeutics, Pfizer on Sept. 2 for "Protease-activating CD45-gate CAR" (California Inventors)

ALEXANDRIA, Va., Sept. 3 -- United States Patent no. 12,404,315, issued on Sept. 2, was assigned to Allogene Therapeutics Inc. (South San Francisco, Calif.) and Pfizer Inc. (New York).

"Protease-activating CD45-gate CAR" was invented by Shanshan Lang (San Mateo, Calif.), Thomas John Van Blarcom (Oakland, Calif.), Michael Thomas Bethune (Castro Valley, Calif.), Siler Panowski (Berkeley, Calif.), Nguyen Tan (Berkeley, Calif.), Yi Zhang (Foster City, Calif.), Barbra Johnson Sasu (San Francisco) and Zhe Li (Burlingame, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A reversibly gated effector polypeptide e.g. a chimeric antigen receptor (protease-activating CD45-gate CAR) comprising an extracellular CD45 ...