ALEXANDRIA, Va., June 25 -- United States Patent no. 12,338,485, issued on June 24, was assigned to Alida Biosciences Inc. (San Diego).
"Multiplexed profiling of RNA and DNA modifications" was invented by Gudrun Stengel (San Diego), Byron Purse (San Diego), Yu-Hsien Hwang-Fu (San Diego) and Jerome Santos (San Diego).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are compositions and methods for the multiplexed profiling of RNA and DNA modifications across transcriptomes and genomes, respectively. The methods combine molecular recognition of non-canonical features (e.g., base modifications, backbone modifications, lesions, and/or structural elements) of a target nucleic acid with a step of writ...