US Patent Issued to Alexion Pharmaceuticals on Oct. 7 for "Alkaline phosphatase polypeptides and methods of use thereof" (Connecticut, Massachusetts Inventors)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,433,938, issued on Oct. 7, was assigned to Alexion Pharmaceuticals Inc. (Boston).

"Alkaline phosphatase polypeptides and methods of use thereof" was invented by Walter C. Voegtli (Killingworth, Conn.), Michael Baranello (Boston) and Keith Bouchard (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Featured are polypeptides that include soluble alkaline phosphatases, mutants, fragments, fusion proteins thereof, and methods of use thereof, for treating bone mineralization disorders, such as hypophosphatasia (HPP), and symptoms thereof. The polypeptides include a soluble alkaline phosphatase (sALP) or fragment thereof, which is derived from a naturally ...