US Patent Issued to Albert-Ludwigs-Universitaet Freiburg on Dec. 9 for "Modified Cas9 system having a dominant negative effector on non-homologous end-joining fused thereto and its use for improved gene editing" (German Inventors)

ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,492,389, issued on Dec. 9, was assigned to Albert-Ludwigs-Universitaet Freiburg (Freiburg, Germany).

"Modified Cas9 system having a dominant negative effector on non-homologous end-joining fused thereto and its use for improved gene editing" was invented by Claudio Mussolino (Freiburg, Germany), Toni Cathomen (Freiburg, Germany), Tatjana Cornu (Freiburg, Germany) and Antonio Carusillo (Freiburg, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to modified Cas9 nuclease comprising a substantial part of a Cas9 nuclease and fused thereto at least one substantial part of a dominant negative effector on non-homologous end-j...