US Patent Issued to ALBERT EINSTEIN COLLEGE OF MEDICINE on Oct. 14 for "Compounds useful for inhibiting RAF dimers" (New York Inventors)

ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,440,494, issued on Oct. 14, was assigned to ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, N.Y.).

"Compounds useful for inhibiting RAF dimers" was invented by Evripidis Gavathiotis (Roslyn, N.Y.) and Bogos Agianian (Bayside, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure provides compounds of Formula I (Formula I) (c) And the pharmaceutically acceptable salts thereof. The A, B, C, and D rings and the variables, RA, RB, RC, RD, L0, L1, L2, and L2, are defined herein. Compounds and salts of Formula I are useful as inhibitors of RAF kinase dimerization, including dimerization of wild type and mutant BRAF kinases. The disclosure includes ph...