US Patent Issued to Albert Einstein College of Medicine on March 18 for "Methods and compositions for determining the functional activity of DNA double strand break repair pathway molecules for assessing germline risk of cancer" (New York Inventors)

ALEXANDRIA, Va., March 19 -- United States Patent no. 12,253,524, issued on March 18, was assigned to Albert Einstein College of Medicine (Bronx, N.Y.).

"Methods and compositions for determining the functional activity of DNA double strand break repair pathway molecules for assessing germline risk of cancer" was invented by Harry Ostrer (New York), Johnny C. Loke (Nanuet, N.Y.) and Alexander Pearlman (New York).

According to the abstract* released by the U.S. Patent & Trademark Office: "Heritable mutations in the BRCA1 and BRCA2 and other genes in the DNA double-strand break (DSB) repair pathway increase risk of breast, ovarian and other cancers. In response to DNA breaks, the proteins encoded by these genes bind to each other and are tra...