ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,454,548, issued on Oct. 28, was assigned to AJINOMOTO Co. INC. (Tokyo).

"Method for producing refolded protein by using flow microreactor, and protein refolding apparatus" was invented by Daisuke Ejima (Kawasaki, Japan), Yuichi Nakahara (Kawasaki, Japan), Keisuke Kato (Kawasaki, Japan) and Masayo Date (Kawasaki, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a method for producing a refolded protein, the method comprising a step for mixing, inside a micro mixer, a buffer and a solubilization solution for a protein that has lost higher order structure or that has become insoluble."

The patent was filed on May 5, 2021...