ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,384,835, issued on Aug. 12, was assigned to Ablynx N.V. (Ghent-Zwijnaarde, Belgium).
"Cysteine linked nanobody dimers" was invented by Daniel Janssen (Puurs, Belgium), Peter Schotte (De Pinte, Belgium), Francis Descamps (Roeselare, Belgium), Carlo Boutton (Wielsbeke, Belgium) and Peter Casteels (Erpe-Mere, Belgium).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to dimers comprising a first polypeptide and a second polypeptide, wherein each of said first and second polypeptide comprises at least one immunoglobulin single variable domain (ISVD) and a C-terminal extension comprising a cysteine moiety (preferably at the C-termin...