ALEXANDRIA, Va., Dec. 2 -- United States Patent no. RE50,682, issued on Dec. 2, was assigned to Ablynx NV (Ghent-Zwijnaarde, Belgium) and Sanofi (Paris).
"Immunoglobulin variable domains" was invented by Marie-Ange Buyse (Merelbeke, Belgium) and Carlo Boutton (Wielsbeke, Belgium).
According to the abstract* released by the U.S. Patent & Trademark Office: "VH domain, in which: (i) the amino acid residue at position 112 is one of K or Q; and/or (ii) the amino acid residue at position 89 is T; and/or (iii) the amino acid residue at position 89 is L and the amino acid residue at position 110 is one of K or Q; and (iv) in each of cases (i) to (iii), the amino acid at position 11 is preferably V; and in which said VH domain contains a C-termina...