US Patent Issued to ABIOCHEM BIOTECHNOLOGY (GROUP) on Jan. 13 for "Transaminase mutant, immobilized transaminase and use in preparation of sitagliptin" (Chinese Inventors)

ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,522,809, issued on Jan. 13, was assigned to ABIOCHEM BIOTECHNOLOGY (GROUP) Co. LTD. (Shanghai).

"Transaminase mutant, immobilized transaminase and use in preparation of sitagliptin" was invented by Zhenhua Tian (Shanghai), Zhanbing Cheng (Shanghai), Shaonan Ding (Shanghai), Qi Jiao (Shanghai), Juxi Hao (Shanghai) and Yongliang Ji (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is use of immobilized transaminase in preparation of sitagliptin and/or (R)-3-amino-1-morpholine-4-(2,4,5-trifluorophenyl)-1-butanone. The immobilized transaminase comprises resin and a transaminase mutant, the amino acid sequence of the transaminase mutant is as...