ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,319, issued on Oct. 7, was assigned to AbClonal Science Inc. (Woburn, Mass.).
"Double tagged Serratia Marcescens nuclease" was invented by Dapeng Sun (Lexington, Mass.), Aine Quimby (Newburyport, Mass.) and Zhenyu Zhu (Lynnfield, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Either wild type or mutant Serratia marcescens Nuclease ("SMN") is engineered to display a C-terminal Chitin Binding Domain (CBD-tag), followed, at the C-terminus side of the CBD-tag, by a poly-histidine tag (His-tag), where the His-tag is preferably a 6-mer and preferably is preceded by a Gly-Ser linker, thereby generating a recombinant SMN protein that retains dual affin...