US Patent Issued to AbClonal Science on July 15 for "T4 DNA ligase variants with increased resistance to salt" (Massachusetts Inventors)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,359,185, issued on July 15, was assigned to AbClonal Science Inc. (Woburn, Mass.).

"T4 DNA ligase variants with increased resistance to salt" was invented by Alicia DiCicco (Salem, Mass.), Zhenyu Zhu (Lynnfield, Mass.) and Aine Quimby (Newburyport, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A number of T4 DNA ligase mutants exhibiting enhanced ligation activity in the presence of high salt concentrations compared to the wild-type ligase were engineered, characterized, and selected via gel electrophoresis of ligation products from a standard ligation assay. Ligase catalyzes the formation of phosphodiester bonds between the 5' and 3' ends of com...