US Patent Issued to Aarhus Universitet on Sept. 16 for "Macrocycles comprising a 4-amido-2,4-pentadienoate moiety for the treatment of hypoxic cancers" (Danish Inventors)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,415,789, issued on Sept. 16, was assigned to Aarhus Universitet (Aarhus C, Denmark).

"Macrocycles comprising a 4-amido-2,4-pentadienoate moiety for the treatment of hypoxic cancers" was invented by Thomas Bjornskov Poulsen (Hojbjerg, Denmark), Per Hjerrild (Aarhus C, Denmark), Kristian Mark Jacobsen (Harlev J, Denmark) and Thomas Torring (Hojbjerg, Denmark).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides macrocyclic compounds comprising a 4-amido-2,4-pentadienoate (APD) moiety. The compounds exhibit toxicity that is selective to the hypoxic micro-environments often found in cancerous tissues. The disclosed compounds are th...