ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,288, issued on Sept. 23, was assigned to A-Alpha Bio (Seattle).
"Interferon alpha-2 variants" was invented by Emily Engelhart (Seattle), Davis Goodnight (Seattle), Kyle Minch (Seattle) and Ryan Swanson (Seattle).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are human interferon alpha-2 (IFNA2) variants that have decreased or no detectable binding to the human interferon-alpha/beta receptor beta 2 (IFNAR2) as compared to the wild-type human IFNA2 polypeptide. Also provided herein are fusion proteins comprising an antibody or fragment thereof, and a human IFNA2 variant, wherein the IFNA2 variant is covalently linked to the antibody, a...