US Patent Issued to 48Hour Discovery on Sept. 16 for "Genetically-encoded macrocyclic peptide libraries bearing a pharmacophore" (Canadian Inventors)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,416,101, issued on Sept. 16, was assigned to 48Hour Discovery Inc. (Edmonton, Canada).

"Genetically-encoded macrocyclic peptide libraries bearing a pharmacophore" was invented by Ratmir Derda (Edmonton, Canada), Raja Mukherjee (Edmonton, Canada) and Arunika Ekanayake (Edmonton, Canada).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a method of forming a macrocyclic peptide bearing a pharmacophore and said produced macrocyclic peptide, wherein the method comprises the steps of: reacting a peptide with two thiol groups of cysteine side chains with the reactive compound 1,5-dichloropentanedion-2,4. The reaction between the ...