ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,296, issued on Sept. 23, was assigned to 35PHARMA Inc. (Montreal).
"Activin receptor type IIB variants and uses thereof" was invented by Maureen O'Connor-McCourt (Montreal), Vannakambadi K. Ganesh (Montreal), Gilles Tremblay (Montreal) and Gauthier Schang (Montreal).
According to the abstract* released by the U.S. Patent & Trademark Office: "There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and c...