US Patent Issued to 10x Genomics on Oct. 7 for "Probes comprising a split barcode region and methods of use" (Swedish Inventor)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,364, issued on Oct. 7, was assigned to 10x Genomics Inc. (Pleasanton, Calif.).

"Probes comprising a split barcode region and methods of use" was invented by Malte Kuhnemund (Stockholm).

According to the abstract* released by the U.S. Patent & Trademark Office: "In some aspects, the present disclosure relates to methods for reducing the detection of false positive ligation events. In some aspects, the method comprises use of a double split (or "split split") probe. The methods herein have particular applicability in reducing the detection of false positive ligation events when using ligases that have high ligation efficiency but low specificity (e.g., SplintR(R) ligase). Also provi...