ALEXANDRIA, Va., June 5 -- United States Patent no. 12,275,984, issued on April 15, was assigned to 10X GENOMICS INC. (Pleasanton, Calif.).
"Sequential hybridization and quenching" was invented by Felice Alessio Bava (Rome).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides methods for detecting a nucleic acid molecule involving the use of a signal code sequence which corresponds to said nucleic acid molecule, comprising sequential hybridization of detectably labeled probes to allow detection of a signal code sequence. In particular, the present disclosure provides a method of sequential decoding comprising hybridization-directed quenching of detectable moieties that have already b...