US Patent Issued on Sept. 16 for "Adeno-associated virus (AAV) vectors, AAV vectors having reduced capsid deamidation and uses therefor" (Pennsylvania, Maryland Inventors)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,416,016, issued on Sept. 16.

"Adeno-associated virus (AAV) vectors, AAV vectors having reduced capsid deamidation and uses therefor" was invented by James M. Wilson (Philadelphia), April Tepe (Columbia, Md.), Kevin Turner (Newtown Square, Pa.), Joshua Joyner Sims (Philadelphia) and Qiang Wang (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "A recombinant adeno-associated virus (rAAV) vector comprising an AAV capsid having a heterogeneous population of vp1 proteins, a heterogeneous population of vp2 protein and a heterogeneous population of vp3 proteins. The capsid contains modified amino acids as compared to the encoded VP1 amino acid seque...