ALEXANDRIA, Va., Nov. 6 -- United States Patent no. 12,458,624, issued on Nov. 4.

"Deuterium-enriched substituted phenoxyphenyl acetic acids and acylsulfonamides" was invented by Daljit Singh Dhanoa (Del Mar, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention is concerned with deuterium-enriched substituted phenoxy-(3, 4-methylenedioxy)phenylacetic acid and acylsulfonamide derivatives of general structural formula I, their optically active or pure enantiomers and diastereomers, and pharmaceutical salts thereof,These compounds have selective antagonist activity for endothelin receptors or both endothelin and angiotensin II receptors, and are useful in the treatment of diseases mediate...