US Patent Issued on Nov. 25 for "Methods and systems for controlled release of drug cargo via ATP-responsive liposomes" (Tennessee Inventors)

ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,478,690, issued on Nov. 25.

"Methods and systems for controlled release of drug cargo via ATP-responsive liposomes" was invented by Jinchao Lou (Knoxville, Tenn.), Jennifer Schuster (Knoxville, Tenn.), Francisco Nicolas Barrera Olivares (Knoxville, Tenn.) and Michael Douglas Best (Knoxville, Tenn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Dimer and monomer molecules according to general formulas (I) or (II) are useful as lipid switch molecules when incorporated into a membrane of a liposome.wherein R1 is a hydrophobic tail having at least 6 carbons and wherein R2 is selected from the group consisting of -NH2,wherein, for the dimer, the linker is a ...