US Patent Issued on March 18 for "Methods and compositions for KRAS inhibitors" (Texas Inventors)

ALEXANDRIA, Va., March 19 -- United States Patent no. 12,251,383, issued on March 18.

"Methods and compositions for KRAS inhibitors" was invented by Alemayehu Gorfe Abebe (Houston), Michael J. McCarthy (Houston), Cynthia V. Pagba (Houston) and Priyanka Prakash Srivastava (Houston).

According to the abstract* released by the U.S. Patent & Trademark Office: "In one aspect, the disclosure relates to compounds that are inhibitors of KRAS, and the disclosed compounds are allosteric inhibitors of KRAS which render them extremely useful for therapeutic intervention in a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, e.g., cancer. In various aspects, the disclosed compounds are substituted 7-(piperazin-1-...