ALEXANDRIA, Va., June 25 -- United States Patent no. 12,338,451, issued on June 24.
"Compositions useful in treatment of metachromatic leukodystrophy" was invented by James M. Wilson (Philadelphia) and Juliette Hordeaux (Philadelphia).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is a recombinant adeno-associated virus (rAAV) having an AAVhu68 capsid and a vector genome which comprises a nucleic acid sequence encoding a functional human arylsulfatase A (ARSA). Also provided are a production system useful for producing the rAAV, a pharmaceutical composition comprising the rAAV, and a method of treating a subject having metachromatic leukodystrophy, or ameliorating symptoms of metachromatic leukodystr...