US Patent Issued on June 17 for "Non-immunogenic engineered tissue and methods of producing and using the same" (German Inventor)

ALEXANDRIA, Va., June 19 -- United States Patent no. 12,331,318, issued on June 17.

"Non-immunogenic engineered tissue and methods of producing and using the same" was invented by Lothar Germeroth (Goettingen, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides a method of producing a non-immunogenic (bio)engineered tissue from pluripotent stem cells or pluripotent stem cell derivatives, the respective cells being deficient of MHC class I molecules and comprising an immunomodulatory protein on their surface, wherein the method comprises inducing the differentiation of the pluripotent stem cells into a cell type that is essential for the function of the engineered tissue under condit...