US Patent Issued on June 17 for "Methods and compositions for diagnosing and treating, germline mismatch repair deficiencies, lynch syndrome and assessing germline risks of cancer" (New York Inventors)

ALEXANDRIA, Va., June 19 -- United States Patent no. 12,331,345, issued on June 17.

"Methods and compositions for diagnosing and treating, germline mismatch repair deficiencies, lynch syndrome and assessing germline risks of cancer" was invented by Harry Ostrer (New York), Johnny C. Loke (Valley Cottage, N.Y.) and Ishraq Alim (New York).

According to the abstract* released by the U.S. Patent & Trademark Office: "Heritable pathogenic variants in the mismatch repair (MMR) pathway, also known as Lynch Syndrome (LS), can lead to the development of colon cancer and other cancers. Following mismatch, a complex of proteins consisting of MLH1, MSH2, MSH6 and PMS2 translocate into the nucleus to signal recruitment of repair mechanisms. Flow cytome...