ALEXANDRIA, Va., July 9 -- United States Patent no. 12,351,847, issued on July 8.
"Methods for the improved formation of acarbose" was invented by Alfred Puhler (Bielefeld, Germany), Jorn Kalinowski (Bielefeld, Germany), Susanne Schneiker-Bekel (Halle, Germany), Marcus Persicke (Bielefeld, Germany) and Lena Schaffert (Cologne, Germany).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to Actinomycetales strains for the improved formation of acarbose. Provided are Actinomycetales strains which are engineered to overexpress dTDP-D-glucose-4,6-dehydratase (AcbB) and/or uridyltransferase (GtaB). Also provided are Actinomycetales strains which are engineered to have a reduced or absent e...