US Patent Issued on Jan. 27 for "Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins" (California Inventor)

ALEXANDRIA, Va., Jan. 28 -- United States Patent no. 12,537,071, issued on Jan. 27.

"Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins" was invented by David Gordon Bermudes (Woodland Hills, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Tumor-selective expression of therapeutic molecules by bacteria is achieved by one or more AND, NOR, OR, NOT and/or NAND gate genetic circuits. The therapeutic molecules can be proteins, metabolites or catabolites, and may also be immunotherapeutics or immunotherapeutic cytotoxins. Single or multiple expression components may be used. Tumor selective expression of multimeric proteins utilizes multimerizatio...