ALEXANDRIA, Va., Jan. 20 -- United States Patent no. 12,528,765, issued on Jan. 20.
"Continuous synthesis method of 2-acetamido-5-nitroanisole" was invented by Qikui Liu (Jinan, China) and Song Yang (Jinan, China).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to the field of organic synthesis and discloses a continuous synthesis process of 2-acetamido-5-nitroanisole; said process uses a microchannel continuous flow reactor as the main reaction equipment and o-anisidine as the starting materials to synthesize 2-acetamido-5-nitroanisole continuously via pre-acylation, amidation, and nitration reactions; through the use of a composite amidation reagent, the process can reduce the r...