US Patent Issued on Feb. 3 for "Cocrystals derivatives of apixaban" (Argentinean Inventor)

ALEXANDRIA, Va., Feb. 3 -- United States Patent no. 12,540,135, issued on Feb. 3.

"Cocrystals derivatives of apixaban" was invented by Guilherme Savoi (Buenos Aires, Argentina).

According to the abstract* released by the U.S. Patent & Trademark Office: "New derivatives of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo [3,4c] pyridine-3-carboxamide (Apixaban) able to increase its water solubility. These derivatives are cocrystals derivatives ofApixaban of different acids, from which the most outstanding are the following: Apixaban Malonic Acid derivative, Apixaban-a-Ketoglutaric Acid derivative, Apixaban-Gallic Acid derivative, Apixaban-Maleic Acid derivative, Apixaban-L-Tartaric Acid derivative...