ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,544,455, issued on Feb. 10.
"Targeted poly(beta-amino ester)s" was invented by Ozgul Tezgel (Paris), Frederic Mourlane (Nice, France), Renaud Vaillant (Gentilly, France) and Cecile Bauche (Paris).
According to the abstract* released by the U.S. Patent & Trademark Office: "Nontoxic, targeted poly beta-amino esters (PBAEs) are synthesized by using click chemistry to attach a targeting moiety. The click chemistry uses a dienophile, such as a strained alkene ring, and a diene, such as tetrazine, to provide rapid attachment of targeting moieties to PBAE polymers and nanoparticle surfaces containing them. Targeting moieties such as aptamers, antibodies or antibody-like proteins can be quic...