US Patent Issued on Feb. 10 for "Anti-TREM2 agonist antibodies and antigen-binding fragments thereof that can increase levels of soluble TREM2 in serum and brain tissue" (California Inventors)

ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,545,729, issued on Feb. 10.

"Anti-TREM2 agonist antibodies and antigen-binding fragments thereof that can increase levels of soluble TREM2 in serum and brain tissue" was invented by Buxin Chen (San Marcos, Calif.), Yubin Wang (San Diego), Xin Du (La Jolla, Calif.), Hsueh-Chung Lu (San Diego) and Lei Huang (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to antibodies that bind the extracellular domain of human TREM2 and the use of anti-TREM2 antibodies in therapy, prophylaxis, diagnosis, screening, and monitoring, including for increasing levels of soluble TREM2 (sTREM2) in serum and brain, increasing phagocytosis...