ALEXANDRIA, Va., Dec. 31 -- United States Patent no. 12,509,681, issued on Dec. 30.
"Antisense oligonucleotides directed to huntingtin" was invented by Gene Hung (San Diego), C. Frank Bennett (Carlsbad, Calif.), Janet M. Leeds (Encinitas, Calif.) and Susan M. Freier (San Diego).
According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin's disease in an individual susceptible ...