Geneva, May 20 -- International Clinical Trials Registry received information related to the study (ISRCTN49320109) titled 'A CAR T trial for amyloid light chain amyloidosis (AL Amyloid)' on May 6.
Study Type: Interventional
Study Design:
Interventional non randomized (Safety, Efficacy)
Primary Sponsor: University College London Cancer Trials Centre
Condition:
AL Amyloid
Cancer
Intervention:
There are 2 cohorts in this trial:
Cohort 1 - D8 CAR T cells (CAR T cells targeting BCMA).
Cohort 2 - D8/ CAT CAR T cells (CAR T cells targeting both BCMA and CD19)
Both cohorts have 2 dose levels: 50 x 10^6 and 150 x 10^6
When the trial opens, patients will be recruited into the lower dose of cohort 1 (D8 CAR T cells, dose level 50 x 10^6...