U.S., May 3 -- ClinicalTrials.gov registry received information related to the study (NCT06955520) titled 'Vonaprazan Versus Esomeprazole for Healing of LA Grade B or Higher Esophagitis After POEM: A Non-Inferiority Randomized Trial' on April 25.
Brief Summary: Peroral Endoscopic Myotomy (POEM) is a well-established treatment for achalasia; however, it is frequently associated with gastroesophageal reflux disease (GERD), with many patients developing LA grade B or higher esophagitis. Proton pump inhibitors (PPIs) like Esomeprazole are the standard treatment, but Vonaprazan, a potassium-competitive acid blocker (P-CAB), offers superior acid suppression and may provide enhanced healing in post-POEM reflux esophagitis.
Primary Objective:
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