U.S., Aug. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07108244) titled 'Use of [18F]FET PET-MRI to Improve Detection of Pituitary Adenomas in Cushing's Disease' on July 25.
Brief Summary: In ACTH-dependent hypercortisolism it is important to distinguish between Cushing's disease (CD), with ACTH production by a pituitary neuroendocrine tumour (PitNET) and Cushing's syndrome (CS), with ectopic ACTH production. Bilateral inferior petrosal sinus sampling (IPSS) is the gold standard for this distinction, with a diagnostic accuracy of 98%. However, IPSS is an invasive procedure and an indi-rect diagnostic method, rarely providing reliable data on the exact location of the PitNET. This has a major impact on the...