U.S., Oct. 3 -- ClinicalTrials.gov registry received information related to the study (NCT07204392) titled 'Unveiling the Germline Predisposition to Myeloproliferative Neoplasms' on Sept. 24.
Brief Summary: The classic Ph-negative myeloproliferative neoplasms (MPN) are a group of clonal hematopoietic disorders caused by a dysregulated JAK/STAT signal transduction because of acquired somatic mutations of JAK2, CALR or MPL genes. They are sporadic diseases but there are several lines of evidence that support the role of germline factors in the pathogenesis of MPN: the existence of familial clustering, the presence of more than one clone in some patients, the known existence of common polymorphisms that cause predisposition to MPN.
In this s...