Clinical Trial: The Role of mGluR5 in CBT-I

U.S., July 23 -- ClinicalTrials.gov registry received information related to the study (NCT07076342) titled 'The Role of mGluR5 in CBT-I' on July 14.

Brief Summary: This is mechanistic clinical trial that evaluates the role of one of the glutamate receptors (mGluR5) in cognitive behavioral therapy for insomnia (CBT-I) as a common pathway in improving sleep and depression.

Study Start Date: July, 2025

Study Type: INTERVENTIONAL

Condition: Major Depressive Disorder (MDD)

Intervention: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia

Cognitive Behavioral Therapy for Insomnia (CBT-I) will be delivered through an online program, Sleep Healthy Using The Internet Sleep Healthy Using The Internet (SHUTi)

DRUG: PET Scan with [11C]ABP68...