U.S., Nov. 11 -- ClinicalTrials.gov registry received information related to the study (NCT07226453) titled 'Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma' on Nov. 06.
Brief Summary: This is a multi-site study of the pharmacodynamic effects and efficacy of metformin in children and young adults with recurrent or progressive Posterior Fossa Group A (PFA) ependymoma.
Study Start Date: Feb. 28, 2026
Study Type: INTERVENTIONAL
Condition:
Posterior Fossa Ependymal Tumor
Intervention:
DRUG: Metformin
Given orally (PO)
PROCEDURE: Planned Surgical Resection
Undergo planned surgery as part of regular care
PROCEDURE: Magnetic Resonance Imaging (MRI)
Undergo MRI imaging
PROCEDURE: Sp...