U.S., Dec. 4 -- ClinicalTrials.gov registry received information related to the study (NCT07262008) titled 'Sustained Mood Improvement With Laughing Gas Exposure' on Nov. 21.
Brief Summary: Multi-centre, parallel group, blinded, 1:1 randomized controlled trial to determine the effect of nitrous oxide on reducing symptoms of depression in patients with treatment resistant depression.
Study Start Date: Feb. 01, 2026
Study Type: INTERVENTIONAL
Condition:
Major Depressive Disorder
Treatment Resistant Depression
Intervention:
DRUG: Inhalation of Nitrous oxide (Laughing gas) + intravenous saline
Nitrous oxide at an inspiratory concentration of 50% with concurrent intravenous saline (20ml) for one hour.
DRUG: inhalation of %100 oxygen + i...