Clinical Trial: Substance P-Induced Migraine Attacks Without Aura

U.S., May 7 -- ClinicalTrials.gov registry received information related to the study (NCT06959004) titled 'Substance P-Induced Migraine Attacks Without Aura' on May 05.

Brief Summary: Substance P is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether its administration can trigger migraine attacks in individuals with migraine without aura.

Study Start Date: May 12

Study Type: INTERVENTIONAL

Condition: Migraine

Intervention: DRUG: Substance P

The participants will receive a continuous intravenous infusion of 20 mL of substance P (4.0 pmol/kg/min) over 20 minutes.

DRUG: Placebo

The participants will receive a continuous intravenous infusion of 20 mL of placebo (isotonic saline) over 20 minutes....