U.S., Feb. 19 -- ClinicalTrials.gov registry received information related to the study (NCT06831643) titled 'Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure' on Jan. 03.
Brief Summary: Acute liver failure is a multisystem disorder characterized by a syndrome of jaundice, coagulopathy, and encephalopathy with high mortality in the absence of liver transplantation. The pathogenesis of multiorgan failure (MOF) in ALF has been attributed to the release of damage-associated molecular patterns (DAMPs) from injured hepatic cells and microbial pathogen-associated molecular patterns (PAMPs) in the presence of superimposed infection or bacterial translocation.The innate immune cells activated by PAMPs and DAMPs produ...