U.S., Feb. 25 -- ClinicalTrials.gov registry received information related to the study (NCT06841861) titled 'Spermatogonial Differentiation Via Testicular Organoid' on April 26, 2024.
Brief Summary: Purpose:
This clinical trial aims to explore the potential for human sperm production in vitro by sustaining a laboratory-cultured adult testicular environment. It also seeks to identify genetic factors contributing to human sterility and failed spermatogenesis. The study's primary objectives include:
1. Identifying genomic markers associated with sterility and failed spermatogenesis.
2. Developing an ex vivo (outside the body) testis "organ-on-a-chip" ("iTestis") to support stem cell cultivation.
3. Determining whether human spermatogenesi...