U.S., July 9 -- ClinicalTrials.gov registry received information related to the study (NCT07053293) titled 'SGLT2i, Hepatic Glucose Production, and SNS' on June 26.
Brief Summary: In this study, we will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) and type 1 diabetes (T1D), and that the increases in ketone production and lipolysis can be prevented by concomitant administration of the thiazolidinedione pioglitazone. We will conduct five distinct experiments to test this hypothesis in patients with T2D and T1D.
Sub-study of HSC20230475H. To examine the role of the SNS on the empagliflo...